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Some degree of immunophenotype overlap between CLL, marginal zone lymphoma, and lymphoplasmacytic lymphoma exists. Should the diagnosis is uncertain depending on peripheral blood movement cytometry, lymph node biopsy really should be pursued.
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See "Targeted therapies in CLL: mechanisms of resistance and methods for management" on website page 471.
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Deep, specific future-technology sequencing has discovered that subclonal mutations (i.e., People present in just a fraction of tumor cells) is usually detected for all driver genes and so are connected with fast sickness progression and MBL77 bad consequence.11–thirteen This is particularly applicable for TP53
Are BTK and PLCG2 mutations important and adequate for ibrutinib resistance in chronic lymphocytic leukemia?
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